Activation of gene expression by human herpesvirus 6 is reporter gene-dependent
نویسندگان
چکیده
منابع مشابه
Activation of Gene Expression by Human Herpes Virus 6
Human herpes virus type 6 (HHV-6) was first detected by Salahuddin et al. [6] and has been isolated from patients with lymphoproliferative and immunosuppressive conditions. HHV -6 is the causative agent of exanthem subitum and the majority of the adult popUlation has been infected with this virus. HHV -6 is able to grow in lymphoblastoid cell lines. Previous studies have shown that coinfection ...
متن کاملActivation of NF-kappaB-dependent gene expression by silica in lungs of luciferase reporter mice.
Occupational exposure to crystalline silica is associated with the development of pulmonary inflammation and silicosis, yet how silica initiates pulmonary fibrosis and which cell types are involved are unclear. In studies here, we hypothesized that silica particles interact initially with pulmonary epithelial cells and alveolar macrophages (AMs) to cause transcriptional activation of nuclear fa...
متن کاملReporter gene expression for monitoring gene transfer.
The use of reporters such as green fluorescent protein (GFP) and firefly luciferase permit highly sensitive and nondestructive monitoring of gene transfer and expression. Modifications in GFP which increase intensity and thermostability, as well as alter its spectral qualities, have facilitated the use of GFP in a variety of gene transfer methods. Improvements in imaging technologies and their ...
متن کاملIdentification of human herpesvirus 6 uracil-DNA glycosylase gene.
Uracil-DNA glycosylase encoded in many species functions as a DNA repair enzyme that removes uracil residues from DNA. To investigate the potential function of uracil-DNA glycosylase encoded by human herpes-virus 6 (HHV-6), we sequenced a DNA clone (pSTY09), identified an open reading frame of 765 bp and compared the putative amino acid sequence with other uracil-DNA glycosylases, by computer a...
متن کاملRta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression.
Human herpesvirus 8 (HHV-8)/Kaposi sarcoma-associated herpesvirus (KSHV) is linked to a number of malignancies thought to be driven by cytokines, including interleukin-6 (IL-6). Rta, a transcriptional activator encoded by HHV-8/KSHV, activates the viral lytic cycle leading to the expression of several viral genes implicated in viral pathogenesis. However, the effect of HHV-8/KSHV Rta on cellula...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1991
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-72-5-1123